Personally I prefer 150 gr. in my Ruger 7 Mag. From 50 yds to 300yds+, I have had NO complaints at all. I have shot high end bullets as well as your normal Remington, Winchester, etc in a vise and in hunting situations. After lots of money spent on ammo, and ALOT of deer on the ground, Remington Core-Lock 150 gr have out performed all in my opinion. Accuracy, bullet expansion, down range capability, and just plain knock down power have sold me. Although as with most high caliber guns, I have had issues with exploding bullets at close range when hitting a rib bone, but the outcome is ALWAYS a down deer immediately. 7mmMag/300 Mag, etc are great for wide open shots, but not great for shooting into semi thick to thick brush. The high velocity of the bullets will usually make nearly all bullets explode or deflect horribly when hitting a limb or something at close range no matter what brand you choose. The heavier bullets may help with this but I doubt very much, just my opinion. I know you asked about a 300 mag, my hunting buddy shoots one and he and I have had the same issues, success, and failures with my 7 mag and his 300 mag. Always remember to shoot the same bullets (brand, grain, same lot #) when hunting that you sighted your rifle in with. You probably know that, just a reminder for those who dont! Good Luck!!